2202-63-3

Basic information

• Product Name: ((R)-2-Chloro-1-phenyl-ethyl)-dimethyl-amine; hydrochloride
• Synonyms: ((R)-2-Chloro-1-phenyl-ethyl)-dimethyl-amine; hydrochloride
• CAS NO: 2202-63-3
• Molecular Weight: 220.142
• Mol File: 2202-63-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((R)-2-Chloro-1-phenyl-ethyl)-dimethyl-amine; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-2-Chloro-1-phenyl-ethyl)-dimethyl-amine; hydrochloride(2202-63-3)
• EPA Substance Registry System: ((R)-2-Chloro-1-phenyl-ethyl)-dimethyl-amine; hydrochloride(2202-63-3)

Safety Data

• Hazardous Substances Data: 2202-63-3(Hazardous Substances Data)

Upstream product

• 29810-09-1 (R)-2-(dimethylamino)-2-phenylacetic acid 
• 2202-65-5 (R)-2-(dimethylamino)-2-phenylethanol 
• 1128-33-2 (R)-2-(dimethylamino)-2-phenylethanol hydrochloride 

Downstream Products

• 74492-08-3 (R)-phenyl-glyphos 
• 98-86-2 acetophenone 

Relevant articles and documents

Chiral (β-Aminoalkyl)phosphines. Highly Efficient Phosphine Ligands for Catalytic Asymmetric Grignard Cross-Coupling

New chiral (β-aminoalkyl)phosphines, RCH(NMe2)CH2PPh2 , were prepared by starting with optically active amino acids.The phosphines were used as ligands for nickel-catalyzed asymmetric cross-coupling of 1-arylethyl Grignard reagents (ArMeCHMgCl) with vinyl bromide.Coupling products of over 70percent enantiomeric excess (ee) were obtained in the reaction with the ligand Phephos, Valphos, Ilephos, PhGlyphos, ChGlyphos, or t-Leuphos.A mechanism involving complexation of the magnesium atom in the Grignard reagent with the amino group on the (β-aminoalkyl)phosphine ligand is proposed to account for the high stereoselectivity.The asymmetric cross-coupling was applied to the synthesis of optically active 2-arylpropionic acids.