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220247-69-8

1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester HCL, a derivative of isoquinoline, is a chemical compound synthesized through the esterification of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid with methanol in the presence of hydrochloric acid. It possesses potential pharmacological applications, particularly in the development of neuroprotective and neuroregenerative drugs, making it a promising candidate for the treatment of neurodegenerative diseases.

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  • 220247-69-8 Structure

  • Basic information

    1. Product Name: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL
    2. Synonyms: METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLATE HYDROCHLORIDE;7-METHOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;Methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate HCL;7-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester, hydrochloride;3-Amino-5-(ethoxycarbonyl)benzoic acid;ethyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride
    3. CAS NO:220247-69-8
    4. Molecular Formula: C11H14ClNO2
    5. Molecular Weight: 227.69
    6. EINECS: 1592732-453-0
    7. Product Categories: pharmacetical
    8. Mol File: 220247-69-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL(220247-69-8)
    11. EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL(220247-69-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220247-69-8(Hazardous Substances Data)

220247-69-8 Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester HCL is used as a neuroprotective and neuroregenerative agent for the development of drugs targeting neurodegenerative diseases. Its potential in preclinical trials has shown promising results, indicating its effectiveness in protecting and regenerating neurons, thereby slowing down or halting the progression of these diseases.
Used in Neurological Research:
1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester HCL is used as an inhibitor of acetylcholinesterase, an enzyme associated with Alzheimer's disease. By inhibiting this enzyme, it can potentially improve cognitive function and delay the onset or progression of Alzheimer's disease, offering a new therapeutic approach for this debilitating condition.

Check Digit Verification of cas no

The CAS Registry Mumber 220247-69-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,4 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 220247-69:
(8*2)+(7*2)+(6*0)+(5*2)+(4*4)+(3*7)+(2*6)+(1*9)=98
98 % 10 = 8
So 220247-69-8 is a valid CAS Registry Number.

220247-69-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate,hydrochloride

1.2 Other means of identification

Product number -
Other names METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLATE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220247-69-8 SDS

220247-69-8Relevant articles and documents

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Wang, Zhen,Bian, Huan,Bartual, Sergio G.,Du, Wenting,Luo, Jinfeng,Zhao, Hu,Zhang, Shasha,Mo, Cheng,Zhou, Yang,Xu, Yong,Tu, Zhengchao,Ren, Xiaomei,Lu, Xiaoyun,Brekken, Rolf A.,Yao, Libo,Bullock, Alex N.,Su, Jin,Ding, Ke

supporting information, p. 5911 - 5916 (2016/07/06)

The structure-based design of 1, 2, 3, 4-tetrahydroisoquinoline derivatives as selective DDR1 inhibitors is reported. One of the representative compounds, 6j, binds to DDR1 with a Kd value of 4.7 nM and suppresses its kinase activity with an IC50 value of 9.4 nM, but it is significantly less potent for a panel of 400 nonmutated kinases. 6j also demonstrated reasonable pharmacokinetic properties and a promising oral therapeutic effect in a bleomycin-induced mouse pulmonary fibrosis model.

COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES

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Page/Page column 13; 29, (2010/02/14)

The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invent

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