877861-35-3

Basic information

• Product Name: 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
• Synonyms: 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid;2-Cbz-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
• CAS NO: 877861-35-3
• Molecular Formula: C18H17NO4
• Molecular Weight: 311.33188
• Mol File: 877861-35-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 513.8 °C at 760 mmHg
• Flash Point: 264.5 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 2.22E-11mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid(877861-35-3)
• EPA Substance Registry System: 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid(877861-35-3)

Safety Data

• Hazardous Substances Data: 877861-35-3(Hazardous Substances Data)

Usage

General Description

2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid is a chemical compound with potential pharmaceutical applications. It is a derivative of isoquinoline and contains a carboxylic acid and a benzyloxy carbonyl group. 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid has been studied for its potential role in drug development, particularly in the field of medicinal chemistry. Its unique structure and functional groups make it a promising candidate for the development of new drugs with potential therapeutic uses. Further research is needed to fully understand its pharmacological properties and potential applications in the treatment of various medical conditions.

InChI:InChI=1/C18H17NO4/c20-17(21)15-7-6-14-8-9-19(11-16(14)10-15)18(22)23-12-13-4-2-1-3-5-13/h1-7,10H,8-9,11-12H2,(H,20,21)

Upstream product

• 1187304-45-5 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate 
• 501-53-1 benzyl chloroformate 
• 220247-69-8 methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride 

Relevant articles and documents

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).