220249-14-9Relevant academic research and scientific papers
3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors.
Costanzi,Lambertucci,Volpini,Vittori,Lupidi,Cristalli
, p. 1037 - 1041 (2001)
2,6-Dichloro-1-deazapurine and 2,6-dichloro-3-deazapurine were coupled with 1,2-O-diacetyl-5-O-benzoyl-3-deoxy-beta-D-ribofuranose. Deprotection of the obtained compounds and reaction with liquid ammonia gave the desired 2-chloroadenine nucleosides, which were dechlorinated to afford the corresponding 1-deaza and 3-deazaadenosine derivatives. Biological studies performed on ADA from calf intestine showed that these new nucleosides are inhibitors of the enzyme.
Coupling of 2,6-dichloropurine and 2,6-dichlorodeazapurines with ribose and ribose modified sugars
Vittori,Camaioni,Costanzi,Volpini,Cristalli
, p. 587 - 590 (2007/10/03)
Substituted purine and deazapurine nucleosides are of great interest in medicinal chemistry. Furthermore, 3'-deoxynucleosides exhibit a number of biological activities. In this research the coupling of 2,6-dichloro-1- or 3- deazapurine with protected 3'-d
Synthesis of new 3'-deoxyribonucleosides employing the acid-catalyzed fusion method
Volpini, Rosaria,Camaioni, Emidio,Costanzi, Stefano,Vittori, Sauro,Cristalli, Gloria
, p. 2326 - 2331 (2007/10/03)
Coupling of 4,6-dichloro-1H-imidazo[4,5-c]pyridine (2,6-dichloro-3- deaza-9H-purine) (1) with 1,2-O-di-acetyl-5-O-benzoyl-3-deoxy-β-D- ribofuranose (2), employing the acid-catalyzed fusion method, is reported (Scheme 1). The condensation reaction was regi
