220258-01-5Relevant academic research and scientific papers
Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen
Danoun, Grégory,Tlili, Anis,Monnier, Florian,Taillefer, Marc
supporting information, p. 12815 - 12819 (2013/02/22)
No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups. Copyright
