220271-56-7

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 220271-54-5 (E)-6,6-Bis-benzenesulfonyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-1-furan-3-yl-hex-3-en-2-ol 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 220271-55-6 [(E)-2-(2,2-Bis-benzenesulfonyl-ethyl)-5-furan-3-yl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-dimethyl-silane 

Downstream Products

• 1025938-02-6 4-(2,2-Bis-benzenesulfonyl-ethyl)-2-furan-3-ylmethyl-furan 
• 220271-61-4 [(Z)-9-Benzenesulfonyl-10-(5-furan-3-ylmethyl-furan-3-yl)-3,7-dimethyl-dec-6-enyloxy]-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Palladium catalyzed synthesis of the furanoterpene ircinin-4

A flexible entry into 2,4-disubstituted furan derivatives is outlined employing sulfonium salt 1 as a well accessible starting material. Condensation of the sulfur ylide derived from 1 with aldehydes, palladium catalyzed opening of the vinyloxirane thus formed, and a final oxidative cyclization of the furan ring constitute the key steps of this method. Its utility is exemplified by the first total synthesis of the marine natural product ircinin-4 (2).