220301-74-6Relevant articles and documents
TOCOPHEROL AND TOCOPHERYL QUINONE DERIVATIVES AS CORRECTORS OF LYSOSOMAL STORAGE DISORDERS
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Paragraph 0084-0085, (2016/08/17)
The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorders, restoration of normal mi
Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators
Muller, Thierry,Coowar, Djalil,Hanbali, Mazen,Heuschling, Paul,Luu, Bang
, p. 12025 - 12040 (2007/10/03)
The synthesis of tocopherol fatty alcohols (TFAs), potent microglial activation modulators, was achieved via C-alkylation of trimethylhydroquinone. Several analogs, in particular water-soluble prodrugs, have been synthesized using a Wittig reaction and th