220306-76-3

Upstream product

• 220306-71-8 (E)-(S)-6-Methyl-4-(toluene-4-sulfonylamino)-hept-2-enoic acid methyl ester 
• 247200-54-0 Ethyl (4S,2E)-6-methyl-4-[(4-methylphenylsulfonyl)amino]hept-2-enoate 
• 1220-80-0 (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 130748-67-3 (2S)-N-(4-methylbenzene)-1-sulfonoamido-4-methylpentan-1-ol 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 220324-30-1 N-((S)-1-Formyl-3-methyl-butyl)-4-methyl-benzenesulfonamide 
• 61-90-5 L-leucine 

Downstream Products

• 220306-84-3 Methanesulfonic acid (E)-(S)-6-methyl-4-(toluene-4-sulfonylamino)-hept-2-enyl ester 
• 220306-80-9 Carbonic acid methyl ester (E)-(S)-6-methyl-4-(toluene-4-sulfonylamino)-hept-2-enyl ester 
• 863403-26-3 (+)-(S)-(E)-6-methyl-4-(4-methylbenzylamino)hept-2-en-1-ol 
• 863403-34-3 N-(4-hydroxy-1-isobutyl-but-2-enyl)-N-(4-methyl-benzyl)-2-(toluene-4-sulfonyl)-acetamide 
• 863403-32-1 (-)-(S)-(E)-carbonic acid methyl ester 6-methyl-4-{(4-methylbenzyl)-[2-(toluene-4-sulfonyl)acetyl]amino}hept-2-enyl ester 
• 187532-21-4 (2S,3S)-N-(4-Methylphenylsulfonyl)-3-(2-methylpropyl)-2-vinylaziridine 

Relevant academic research and scientific papers

Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation

A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted γ-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed. The Royal Society of Chemistry 2005.

A 2,3-cis-selective synthesis of aziridines bearing a vinyl group from allyl methyl carbonates and allyl mesylates

A convenient method for the synthesis of synthetically useful chiral 2-vinylaziridines from natural α-amino acids is described. Satisfactory 2,3-cis-selectivities are obtained by exposure of methyl carbonates of various allylic alcohols bearing an N-protected amino group to a catalytic amount of tetrakis(triphenylphosphine)palladium(0), Pd(PPh3)4, in aprotic solvents such as THF. Base-promoted aziridination of mesylates of various N-protected amino allylic alcohols followed by Pd(PPh3)4 catalyzed isomerization for the 2,3-cis-selective synthesis of vinylaziridines is also presented.