247200-54-0

Upstream product

• 16139-79-0 ethyl diphenylphosphonoacetate 
• 220324-30-1 N-((S)-1-Formyl-3-methyl-butyl)-4-methyl-benzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 130748-67-3 (2S)-N-(4-methylbenzene)-1-sulfonoamido-4-methylpentan-1-ol 
• 61-90-5 L-leucine 
• 1220-80-0 (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 220306-76-3 (-)-(S)-(E)-6-methyl-4-(toluene-4-sulfonamido)hept-2-en-1-ol 
• 863403-32-1 (-)-(S)-(E)-carbonic acid methyl ester 6-methyl-4-{(4-methylbenzyl)-[2-(toluene-4-sulfonyl)acetyl]amino}hept-2-enyl ester 
• 863403-34-3 N-(4-hydroxy-1-isobutyl-but-2-enyl)-N-(4-methyl-benzyl)-2-(toluene-4-sulfonyl)-acetamide 
• 863403-26-3 (+)-(S)-(E)-6-methyl-4-(4-methylbenzylamino)hept-2-en-1-ol 

Relevant academic research and scientific papers

Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation

A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted γ-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed. The Royal Society of Chemistry 2005.

Selective synthesis of cis-2-vinyl-3-alkylaziridines and 3-pyrrolines from common intermediates (Z)-4-N-arylsulfonylaminoalk-2-en-1-ols

A simple method for the synthesis of both cis-2-vinylaziridines and 3-pyrrolines from common intermediate (Z)-4-(N-arylsulfonyl)amino-4-alkylbut-2-en-1-ols, is described. Palladium(0)-catalyzed reactions of methyl carbonates of the N-protected (Z)-4-amino-4-alkylbut-2-en-1-ols yield predominantly cis-3-alkyl-2-vinylaziridines. Alternatively, upon exposure to sodium hydride, methanesulfonates derived from N-protected (Z)-4-amino-4-alkylbut-2-en-1-ols give exclusively the corresponding 3-pyrrolines in high yields. A synthesis of biologically important (S)-3,4-dehydroproline is also presented.