22031-52-3Relevant academic research and scientific papers
Electron Impact and Ammonia Chemical Ionization Mass Spectra of n-Azabicycloalkan-(n+1)-ones (m=3-6, n=6-9)
Pihlaja, Kalevi,Vainiotalo, Pirjo,Bernath, Gabor,Goendoes, Gyoergy,Gera, Lajos
, p. 55 - 58 (1986)
Electron impact induced fragmentation of the title compounds obeys a route where the lactam moiety, OCNH, is cleaved first, with the accompanying formation of a cycloalkene ion.This can be verified by low-resolution, high-resolution, B/E and B2/E spectra as well as by collisional activation spectra of, for example, the ions m/z 82 and 67 from 7-azaabicyclooctan-8-one and from cyclohexene.The only, and fairly weak, fragment ions including O and N are +, kH2k-2N>+ (k=5-8) and +.The ammonia chemical ionization spectra are also characteristic for all four lactams and show the same dominant ions in all cases, namely +, +. and +..
Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials
Nivsarkar, Manisha,Thavaselvam,Prasanna,Sharma, Mamta,Kaushik
, p. 1371 - 1373 (2005)
A series of bicyclic N-substituted and unsubstituted β-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.
SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
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Page/Page column 94-95, (2022/02/09)
Compounds of formula (I), processes for their production and their use as pharmaceuticals.
N-acyl-β-lactam derivative, macromolecular compound, and photoresist composition
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Paragraph 0230-0233, (2014/10/28)
Provided are N-acyl-β-lactam derivatives represented by the following general formula, from which a photoresist composition capable of controlling an acid diffusion length to be short is obtained; a polymer obtained by polymerizing the N-acyl-β-lactam derivative represented by the following general formula as one of starting materials; and a photoresist composition containing the polymer, where the structural variables are as defined herein.
Nylon-3 polymers that enable selective culture of endothelial cells
Liu, Runhui,Chen, Xinyu,Gellman, Samuel H.,Masters, Kristyn S.
supporting information, p. 16296 - 16299 (2013/12/04)
Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomat
N-ACYL-B-LACTAM DERIVATIVE, MACROMOLECULAR COMPOUND, AND PHOTORESIST COMPOSITION
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, (2012/06/18)
Disclosed are an N-acyl-β-lactam derivative represented by the following general formula, from which a photoresist composition capable of controlling an acid diffusion length to be short is obtained; a polymer obtained by polymerizing the N-acyl-β-lactam derivative represented by the following general formula as one of starting materials; and a photoresist composition containing the polymer. In the formula, R1 represents a hydrogen atom, a methyl group, or a trifluoromethyl group; W represents an alkylene group or a cycloalkylene group; n represents 0 or 1; and each of R2, R3, R4, and R5 independently represents a hydrogen atom, an alkyl group, a cyclic hydrocarbon group, or an acyloxy group, provided that 1) R2 and R3, or R4 and R5, may be connected to each other to form a substituted or unsubstituted ring which may have an oxygen atom at an arbitrary position, 2) R3 and R4 may be connected to each other to form a substituted or unsubstituted ring which may have an oxygen atom at an arbitrary position, and 3) all of R2, R3, R4, and R5 are not a hydrogen atom at the same time.
Hairpin folding behavior of mixed α/β-peptides in aqueous solution
Lengyel, George A.,Frank, Rebecca C.,Horne, W. Seth
supporting information; experimental part, p. 4246 - 4249 (2011/06/21)
The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the α-helix, mimicry of protein β-sheets is less understood. We report
New compounds
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Page/Page column 9, (2009/07/10)
The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form
Dragovich, Peter S.,Murphy, Douglas E.,Dao, Kimkim,Kim, Sun Hee,Li, Lian-Sheng,Ruebsam, Frank,Sun, Zhongxiang,Tran, Chinh V.,Xiang, Alan X.,Zhou, Yuefen
experimental part, p. 2796 - 2803 (2009/06/28)
A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic acid; compound 12, >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction. An optimized version of the chemistry described avoids the use of chromatographic purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound 12 to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is reported. The preparation of the enantiomer of 12 (compound 15) in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is also described.
Synthesis and antimalarial evaluation of cyclic β-amino acid-containing dipeptides
Sathe, Manisha,Thavaselvam, Duraipandian,Srivastava, Ashish Kumar,Kaushik, Mahabir Parshad
, p. 432 - 443 (2008/09/17)
This paper describes an efficient synthesis and the antiparasitic evaluation of cyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial properties of all these dipeptides have been evaluated in vitro against Plasmodium falciparum a
