220324-59-4

Upstream product

• 103809-91-2 methyl 2-(3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate 
• 1939-99-7 benzenesulfonyl chloride 
• 204322-78-1 [3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid 
• 220324-57-2 methyl 2-(3-(((9H-9-fluorenylmethoxy)carbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate 

Downstream Products

• 220324-61-8 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic acid 

Relevant academic research and scientific papers

Novel benzo-fused lactam scaffolds as factor Xa inhibitors

Rigid benzolactam P3-P2 dipeptide mimics were designed and prepared as potential inhibitors of blood coagulation factor Xa. Methoxy substitution of the tetrahydrobenzazepinone scaffold led to potent and selective inhibitors. The synt

Selective factor Xa inhibitors

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.