220340-37-4

Upstream product

• 98820-73-6 4-carbomethoxy-2,2′-bipyridine 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 3783-38-8 methyl isonicotinate N-oxide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1355019-38-3 4-(methoxycarbonyl)-2-(pyridin-2-yl)pyridine 1-oxide 
• 13737-05-8 2-trimethylstannylpyridine 
• 58481-11-1 methyl 2-chloroisonicotinate 
• 219944-89-5 4-(trimethylsilyl)-methyl-2,2'-bipyridine 
• 219944-94-2 4-(bromomethyl)-2,2'-bipyridine 
• 279681-07-1 acetic acid [2,2']bipyridinyl-4-ylmethyl ester 

Relevant academic research and scientific papers

Use of a Compact Tripodal Tris(bipyridine) Ligand to Stabilize a Single-Metal-Centered Chirality: Stereoselective Coordination of Iron(II) and Ruthenium(II) on a Semirigid Hexapeptide Macrocycle

Fe(II)-coordinating hexapeptides containing three 2,2′-bipyridine moieties as side chains were designed and synthesized. A cyclic hexapeptide having three [(2,2′-bipyridin)-5-yl]-d-alanine (d-Bpa5) residues, in which d-Bpa5 and Gly are alternately arranged with 3-fold rotational symmetry, coordinated with Fe(II) to form a 1:1 octahedral Fe(II)-peptide complex with a single facial-? configuration of the metal-centered chirality. NMR spectroscopy and molecular dynamics simulations revealed that the Fe(II)-peptide complex has an apparent C3-symmetric conformations on the NMR time scale, while the peptide backbone is subject to dynamic conformational exchange between three asymmetric β/γ conformations and one C3-symmetric γ/γ/γ conformation. The semirigid cyclic hexapeptide preferentially arranged these conformations of the small octahedral Fe(II)-bipyridine complex, as well as the Ru(II) congener, to underpin the single configuration of the metal-centered chirality.

Controlling the optical and catalytic properties of artificial metalloenzyme photocatalysts using chemogenetic engineering

Visible light photocatalysis enables a broad range of organic transformations that proceed via single electron or energy transfer. Metal polypyridyl complexes are among the most commonly employed visible light photocatalysts. The photophysical properties of these complexes have been extensively studied and can be tuned by modifying the substituents on the pyridine ligands. On the other hand, ligand modifications that enable substrate binding to control reaction selectivity remain rare. Given the exquisite control that enzymes exert over electron and energy transfer processes in nature, we envisioned that artificial metalloenzymes (ArMs) created by incorporating Ru(ii) polypyridyl complexes into a suitable protein scaffold could provide a means to control photocatalyst properties. This study describes approaches to create covalent and non-covalent ArMs from a variety of Ru(ii) polypyridyl cofactors and a prolyl oligopeptidase scaffold. A panel of ArMs with enhanced photophysical properties were engineered, and the nature of the scaffold/cofactor interactions in these systems was investigated. These ArMs provided higher yields and rates than Ru(Bpy)32+ for the reductive cyclization of dienones and the [2 + 2] photocycloaddition between C-cinnamoyl imidazole and 4-methoxystyrene, suggesting that protein scaffolds could provide a means to improve the efficiency of visible light photocatalysts.

An improved synthesis of hydroxymethyl bipyridines

This account describes quick and efficient syntheses of 4,4'- bis(hydroxymethyl)-2,2'-bipyridine and 4-hydroxymethyl-2,2'-bipyridine from 4,4'-dimethyl-2,2'-bipyridine and 4-methyl-2,2'-bipyridine, respectively, via (trimethylsilyl)methyl-, bromomethyl-, and acetoxymethyl- intermediates. (C) 2000 Elsevier Science Ltd.