220377-96-8

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 102676-61-9 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde 
• 3465-72-3 (E)-3-(1H-imidazol-4-yl)propenoic acid 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 138408-36-3 trans-1-trityl-4-imidazoleacrylic acid methyl ester 
• 54260-89-8 trans-4-imidazoleacrylic acid methyl ester hydrochloride 
• 76-83-5 trityl chloride 
• 102676-60-8 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester 

Downstream Products

• 220377-99-1 5-(1-trityl-1H-imidazol-4-yl)pentan-1-ol 
• 102676-68-6 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pentanoate 

Relevant academic research and scientific papers

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors

A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the

New high affinity H3 receptor agonists without a basic side chain

In this study, we replaced the basic amine function of the known histamine H3 receptor agonists imbutamine or immepip with non-basic alcohol or hydrocarbon moieties. All compounds in this study show a moderate to high affinity for the cloned human H3 receptor and, unexpectedly, almost all of them act as potent agonists. Moreover, in the alcohol series, we consistently observed an increased selectivity for the human H3 receptor over the human H4 receptor, but none of the compounds in this series possess increased affinity and functional activity compared to their alkylamine congeners. In this new series of compounds VUF5657, 5-(1H-imidazol-4-yl)-pentan-1-ol, is the most potent histamine H3 receptor agonist (pKi = 8.0 and pEC50 = 8.1) with a 320-fold selectivity at the human H3 receptor over the human H 4 receptor.