220383-49-3

Upstream product

• 2719-27-9 cyclohexanylcarbonyl chloride 
• 1885-29-6 anthranilic acid nitrile 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 220383-46-0 N-(2-trifluoromethylphenyl)cyclohexanecarboxamide 

Downstream Products

• 433214-37-0 1-[N-(2-cyanophenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)piperazine 
• 433214-49-4 1-[N-(2-cyanophenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(4-indolyl)piperazine 
• 433214-50-7 1-[N-(2-cyanophenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(2-bromo-5-methoxybenzyl)piperazine 

Relevant academic research and scientific papers

A combinatorial approach towards 2-acyl-3-amino-indole derivatives

A widely applicable reaction sequence towards functionalised 2-acyl-3-amino-indole derivatives is presented. A set of 205 indole derivatives were prepared, in a solution phase combinatorial fashion, by coupling a reliable reaction protocol to a rapid puri

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha

Copper-catalyzed oxidative ring closure of ortho-cyanoanilides with hypervalent iodonium salts: Arylation-ring closure approach to iminobenzoxazines

A novel, highly modular synthetic methodology with high functional group tolerance was developed for the construction of iminobenzoxazine derivatives from ortho-cyanoanilides and diaryliodonium triflates via an oxidative arylation-cyclization path. The reaction is supposed to involve the formation of highly active aryl-copper(III) species. In this novel transformation, copper(II) triflate was used as catalyst in 1,2-dichloroethane or ethyl acetate and the reaction takes place at 75 °C in 2-16 h.

1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING

Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are aniline derivatives substituted at position 2 of the aniline ring. The methods comprise the administration of the novel com

1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring

The present invention is directed to novel 1-(N-phenylaminoalkyl)piperazine derivatives substituted at the position 2 of the phenyl ring. Pharmaceutical compositions comprising the compounds of the invention also are contemplated. The compounds of the pre

1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring

Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are aniline derivatives substituted at position 2 of the aniline ring. The methods comprise the administration of the novel com