2204-97-9

Basic information

• Product Name: (4-bromophenyl)(cyclopentyl)methanone
• Synonyms: (4-bromophenyl)(cyclopentyl)methanone;OTAVA-BB 1044116
• CAS NO: 2204-97-9
• Molecular Formula: C₁₂H₁₃BrO
• Molecular Weight: 253.15
• Mol File: 2204-97-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 339.4°C at 760 mmHg
• Flash Point: 77.9°C
• Appearance: /
• Density: 1.391g/cm³
• Vapor Pressure: 9.21E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: (4-bromophenyl)(cyclopentyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromophenyl)(cyclopentyl)methanone(2204-97-9)
• EPA Substance Registry System: (4-bromophenyl)(cyclopentyl)methanone(2204-97-9)

Safety Data

• Hazardous Substances Data: 2204-97-9(Hazardous Substances Data)

Usage

General Description

(4-bromophenyl)(cyclopentyl)methanone is a chemical compound with a molecular formula C13H15BrO. It is a ketone derivative with a bromine substituent on the phenyl ring and a cyclopentyl group attached to the carbonyl carbon. (4-bromophenyl)(cyclopentyl)methanone is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is known to have potential biological activity and is being studied for its pharmacological properties. Additionally, it can be used in various chemical reactions as a versatile building block for the synthesis of more complex organic compounds.

InChI:InChI=1/C12H13BrO/c13-11-7-5-10(6-8-11)12(14)9-3-1-2-4-9/h5-9H,1-4H2

Upstream product

• 3400-45-1 cyclopentanecarboxylic acid 
• 287-92-3 Cyclopentane 
• 1122-91-4 4-bromo-benzaldehyde 
• 108-86-1 bromobenzene 
• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 33240-34-5 cyclopentylmagnesium bromide 

Downstream Products

• 1382486-24-9 C₁₃H₁₅Br 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The present disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides

A number of structural analogues of the known toxicant para- aminopropiophenone (PAPP) have been prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed for alkyl analogues of PAPP (aminophenones 1-20; compound 6 metHb% = 74.1 ± 2). Besides lipophilicity, this structural sub-class suggested there were certain structural requirements for activity, with both branched (10-16) and cyclic (17-20) alkyl analogues exhibiting inferior in vitro metHb induction. Of the four candidates (compounds 4, 6, 13 and 23) evaluated in vivo, 4 exhibited the greatest toxicity. In parallel, aminophenone bioisosteres, including oximes 30-32, sulfoxide 33, sulfone 34 and sulfonamides 35-36, were found to be inferior metHb inducers to lead ketone 4. Closer examination of Hammett substituent constants suggests that a particular combination of the field and resonance parameters may be significant with respect to the redox mechanisms behind PAPPs metHb toxicity.