22041-25-4

Upstream product

• 123-75-1 pyrrolidine 
• 2969-81-5 Ethyl 4-bromobutyrate 

Downstream Products

• 116886-10-3 (pyrrolidinyl-1)-3 propyl-1 cyclohexanol 
• 49637-21-0 4-(pyrrolidin-1-yl)butanoic acid hydrochloride 
• 1040720-89-5 N-[5-(5-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-yl-butyramide formate salt 
• 1040721-25-2 N-[5-(2-difluoromethoxyphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-yl-butyramide formate salt 
• 1040720-97-5 N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide 

Relevant academic research and scientific papers

NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

Syntheses des alkyl-1 cyclanols fonctionnalises aux positions α, β et γ de la chaine hydrocarbonee

We have developed a general and versatile synthesis of N,N-dialkylaminoalkyl-, 1-chloroalkyl-, 1-phenoxyalkyl-, 1-thiophenoxyalkyl-, 1-diethoxyalkyl-, and 1-(1,3-dithiolane)alkylcyclanols in good yields by the reaction of α,ω-bis(bromomagnesio)alkanes with the corresponding functionalized carboxylic acid esters.