220416-57-9

Upstream product

• 79-01-6 Trichloroethylene 
• 102225-88-7 (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol 

Downstream Products

• 359866-19-6 2-[(S)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene 
• 544711-62-8 2-[(S)-1-(pent-4-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene 
• 868843-54-3 (1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one 
• 868843-58-7 (7R,7aS)-7-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-1-one 
• 861143-76-2 (4R,5S)-5-(1-hydroxy-2-propenyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one 
• 868843-52-1 (7R,7aR)-7-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-5,6,7,7a-tetrahydro-3H-pyrrolizine-1-carboxylic acid methyl ester 
• 868843-48-5 trifluoromethanesulfonic acid (7R,7aS)-7-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl ester 

Relevant academic research and scientific papers

Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones

Access to chiral polysubstituted cyclobutanones by [2 + 2]-cycloaddition of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselec

Asymmetric synthesis of cyclobutanones: Synthesis of cyclobut-G

A simple, efficient, and stereoselective approach has been developed for obtaining chiral cis- and trans-disubstituted cyclobutanones from readily available alkyl- and functionalized alkyl-substituted enol ethers. The usefulness of these cyclobutanones is

Dichloroenol ethers x-ray analysis in the mechanistic elucidation of ynol ethers formation

X-ray crystallographic data are provided for dichloroenol ethers (S,E)-2-(1-(1,2-dichlorovinyloxy)ethyl)-1,3,5-triisopropylbenzene (2) and (S,E)-2-(1-(1,2-dichloroprop-1-enyloxy)ethyl)-1,3,5-triisopropylbenzene (3). The former forms colorless crystals (or

Extending the scope of the [2+2] cycloaddition of dichloroketene to chiral enol ethers: Synthesis of (-)-detoxinine

Allylic oxidation of a known lactam, obtained by asymmetric [2+2] cycloaddition of dichloroketene to a chiral enol ether, followed by Beckmann ring expansion and dechlorination, affords a potential intermediate for the synthesis of various natural product

New asymmetric approach to natural pyrrolizidines: Synthesis of (+)-amphorogynine A, (+)-amphorogynine D, and (+)-retronecine

Three natural pyrrolizidines, (+)-amphorogynines A and D and (+)-retronecine, have been prepared from a common lactam intermediate. This central compound, in turn, was synthesized in diastereomerically enriched form through a highly selective [2 + 2]-cycl

Dichloroketene-chiral olefin-based approach to pyrrolizidines: Highly stereocontrolled synthesis of (+)-amphorogynine A

(Matrix presented) A highly stereoselective route to (+)-amphorogynine A, a novel pyrrolizidine recently isolated from the New Caledonian plant Amphorogynine spicata, has been realized. The key step in the approach is a diastereoselective [2 + 2] dichloro

Enantiocontrolled preparation of indolizidines: Synthesis of (-)-2-epilentiginosine and (+)-lentiginosine

A highly stereoselective approach to (-)-2-epilentiginosine and (+)-lentiginosine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether. The two naturally occurring indolizidines are each obtained enantioselectively (≥ 99:1) in ca. 8.5% overall yield.