220417-07-2Relevant academic research and scientific papers
Total synthesis of the chlorinated marine natural product dysamide B
Durow, Amanda C.,Long, G. Cliona,O'Connell, Susan J.,Willis, Christine L.
, p. 5401 - 5404 (2007/10/03)
Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesis of the polychlorinaled marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an α,α-dichloro acid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.
Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid
Akaji, Kenichi,Hayashi, Yuzo,Kiso, Yoshiaki,Kuriyama, Naohiro
, p. 405 - 411 (2007/10/03)
Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull
