53363-88-5

Upstream product

• 2018-66-8 Z-Leu-OH 
• 74-88-4 methyl iodide 

Downstream Products

• 203503-47-3 ((S)-1-Formyl-3-methyl-butyl)-methyl-carbamic acid benzyl ester 
• 33099-08-0 N-benzyloxycarbonyl-N-methyl-L-leucine 
• 220417-07-2 (S)-2-{[(S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of the chlorinated marine natural product dysamide B

Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesis of the polychlorinaled marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an α,α-dichloro acid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.

Novel formation and crystal structure of 2-(2,2,2-trifluoroethylidene)-6-trifluoro-methyl-2,3-dihydro-4H-1,4-oxazin-3- ones from N-acetyl-N-alkyl-α-amino acids

The title compounds (2a-g) were formed from N-acetyl-N-alkyl-α-amino acids (1a-g) on treatment with trifluoroacetic anhydride in the presence of pyridine. The structure of the product (2a) was determined by single crystal X-Ray analysis.

Acyl derivatives

Peptide derivatives provided by the present invention are compounds of the general formula STR1 wherein R1 represents a hydrogen atom or the methyl or hydroxymethyl group or a mono-, di- or trihalomethyl mgroup; R2 represents the cha