22043-07-8

Basic information

• Product Name: 2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinecarbothioamide
• CAS NO: 22043-07-8
• Molecular Formula: C₈H₉N₃O₂S
• Molecular Weight: 211.241
• Mol File: 22043-07-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 372.3°C at 760 mmHg
• Flash Point: 179°C
• Density: 1.649g/cm³
• Vapor Pressure: 4.61E-07mmHg at 25°C
• Refractive Index: 1.856
• CAS DataBase Reference: 2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinecarbothioamide(22043-07-8)
• EPA Substance Registry System: 2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinecarbothioamide(22043-07-8)

Safety Data

• Hazardous Substances Data: 22043-07-8(Hazardous Substances Data)

Usage

Physical form

Yellow to brown powder

Solubility

Sparingly soluble in water

Biological activities

Antioxidant and antimicrobial properties

Potential applications

Pharmaceutical and biotechnology industries

Versatility

Potential use in various fields

Upstream product

• 79-19-6 thiosemicarbazide 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 134952-04-8 4-(5-amino-1,3,4-thiadiazol-2-yl)benzene-1,2-diol 
• 134951-58-9 1-Allyl-3-[5-(3,4-dihydroxy-phenyl)-[1,3,4]thiadiazol-2-yl]-thiourea 

Relevant articles and documents

Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer

Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol-thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated for their antitumor activities. Among them, the most promising compound, 11, showed excellent selective PARP-1 inhibitory activity (IC50 = 29.5 nM) over PARP-2 (IC50 > 1000 nM) and potent anticancer activities toward the SK-OV-3, Bel-7402 and HepG2 cancer cell lines (IC50 = 2.39, 5.45, and 4.60 μM), along with inhibition of tumor growth in an in vivo SK-OV-3 cell xenograft model. Further study demonstrated that compound 11 played an antitumor role through multiple anticancer mechanisms, including the induction of apoptosis and cell cycle arrest, cellular accumulation of DNA double-strand breaks, DNA repair alterations, inhibition of H2O2-triggered PARylation, antiproliferative effects via the production of cytotoxic reactive oxygen species, and autophagy. In addition, compound 11 displayed good pharmacokinetic characteristics and favorable safety. These observations demonstrate that compound 11 may serve as a lead compound for the discovery of new anticancer drugs.

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Basing on a library of thiadiazole derivatives showing anti-trypanosomatidic activity, we have considered the thiadiazoles opened forms and reaction intermediates, thiosemicarbazones, as compounds of interest for phenotypic screening against Trypanosoma b

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase

A series of thiazole derivatives 1-21 were prepared, characterized by EI-MS and 1H NMR and evaluated for α-glucosidase inhibitory potential. All twenty one derivatives showed good α-glucosidase inhibitory activity with IC50 value ran