134952-04-8 Usage
Chemical Structure
Benzene ring with two hydroxyl groups and a 4-(5-amino-1,3,4-thiadiazol-2-yl) moiety attached
This describes the molecular structure of the compound, which is important for understanding its properties and potential applications.
Occurrence
Not commonly found in nature
This indicates that the compound is not naturally occurring and must be synthesized in a laboratory.
Synthesis
Can be synthesized in the laboratory
This suggests that the compound can be produced through chemical reactions, which is important for its potential use in various applications.
Potential Applications
Pharmaceuticals, agrochemicals, and other areas
This highlights the possible industries in which the compound may be used, although further research is needed to fully understand its potential.
Research Status
Further studies and research are needed
This indicates that the compound's potential uses and effects are not yet fully understood, and more research is required to explore its possibilities.
Molecular Weight
Approximately 174.2 g/mol
This is the calculated mass of one mole of the compound, which can be useful for determining the compound's concentration in a solution or its reactivity with other substances.
Functional Groups
Hydroxyl groups, amino group, and thiadiazole ring
These are the specific functional groups present in the compound, which contribute to its chemical properties and potential reactivity with other molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 134952-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,9,5 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134952-04:
(8*1)+(7*3)+(6*4)+(5*9)+(4*5)+(3*2)+(2*0)+(1*4)=128
128 % 10 = 8
So 134952-04-8 is a valid CAS Registry Number.
134952-04-8Relevant articles and documents
Synthesis, antioxidant and antiproliferative activities of 1,3,4-thiadiazoles derived from phenolic acids
Jakovljevi?, Katarina,Mati?, Ivana Z.,Stanojkovi?, Tatjana,Krivoku?a, Ana,Markovi?, Violeta,Joksovi?, Milan D.,Mihailovi?, Nevena,Ni?iforovi?, Marija,Joksovi?, Ljubinka
, p. 3709 - 3715 (2017)
Two 2-amino-1,3,4-thiadiazoles containing phenolic hydroxyl groups were combined with different carboxylic acid chlorides giving sixteen amide derivatives with good antioxidant and antiproliferative potential. The compound 3′c with an adamantane ring displayed excellent DPPH radical scavenging activity and good cytotoxic activity against human acute promyelocytic leukemia HL-60 cells, while 1,3,4-thiadiazole 3′h with 4-chlorophenyl moiety was found to be the most effective in inhibition of survival of lung carcinoma A549 cells. All examined thiadiazoles except 3a and 3′a exerted higher cytotoxic activities on A549 and HL-60 cancer cells when compared with normal fibroblasts MRC-5, pointing to selectivity in their antiproliferative action. Some of the most active novel compounds 3c, 3′c, 3′g and 3′h induced significant increase in the percentage of HL-60 cells in the subG1 cell cycle phase in comparison with the control cells. The induction of cell death in HL-60 cells by these compounds was at least partially dependent on activation of caspase-3 and caspase-8. The compounds 3c and 3′c exerted strong antiangiogenic activity. Furthermore, compounds 3c, 3′c, 3′g and 3′h showed the ability to down-regulate the MMP2 and VEGFA expression levels in the treated HL-60 cells when compared with the control cell samples.
Biologically active thiazolidinone. Part II. Synthesis and fungitoxicities of isolated and fused thiazolidinones derived from thiosemicarbazones
El-Gendy,Abel-Rahman,Fawzy,Mahmoud
, p. 927 - 929 (2007/10/02)
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