220455-59-4Relevant academic research and scientific papers
Synthesis and transporter binding properties of (R)-2β,3β- and (R)- 2α,3α-diaryltropanes
Jiang, Songchun,Chang, An-Chih,Abraham, Philip,Kuhar, Michael J.,Carroll, F. Ivy
, p. 3689 - 3692 (1998)
(R)-2-Aryl-2-tropinone (9) was synthesized from (R)-2-carbomethoxy-3- tropinone (5) and was used as the key intermediate for the synthesis of (R)- 2β,3β- and (R)-2α-3α-diaryltropanes. Inhibition of radioligand binding studies at the dopamine, serotonin, a
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes
Kotturi, Sharadsrikar V.,Jiang, Songchun,Chang, An-Chih,Abraham, Philip,Navarro, Hernán A.,Kuhar, Michael J.,Carroll, F. Ivy
, p. 7437 - 7444 (2007/10/03)
Synthetic procedures were developed for the synthesis of 2β,3β- and 2α,3α-diaryltropanes. These compounds are analogues of the 3-aryltropane-2β-carboxylic acid methyl ester class of monoamine uptake inhibitors, where the 2β-carbomethoxy group has been rep
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter
Meltzer, Peter C.,Blundell, Paul,Huang, Hong,Liu, Shanghao,Yong, Yaw F.,Madras, Bertha K.
, p. 581 - 590 (2007/10/03)
The search for medications for cocaine abuse has focused upon the design of potential cocaine antagonists or cocaine substitutes which interact at the dopamine transporter of mammalian systems. This manuscript describes the synthesis and biological evalua
