Synthesis and transporter binding properties of (R)-2β,3β- and (R)- 2α,3α-diaryltropanes

Article abstract of DOI:10.1016/S0960-894X(98)00673-8

(R)-2-Aryl-2-tropinone (9) was synthesized from (R)-2-carbomethoxy-3- tropinone (5) and was used as the key intermediate for the synthesis of (R)- 2β,3β- and (R)-2α-3α-diaryltropanes. Inhibition of radioligand binding studies at the dopamine, serotonin, a