220456-13-3Relevant academic research and scientific papers
Further studies on total synthesis of sarain A. Efforts toward annulation of the macrocyclic rings
Irie, Osamu,Samizu, Kiyohiro,Henry, James R.,Weinreb, Steven M.
, p. 587 - 595 (1999)
Studies have been conducted on testing strategies for annulation of the two macrocyclic rings onto the central tricyclic nucleus of sarain A (1). In particular, methodology has been developed for introduction into the core of C-3' and C-3 substituents, which are necessary for construction of the 'eastern' and 'western' macrocyclic rings of 1, respectively. Formation of the western ring has been successfully addressed via a ring-closing olefin metathesis strategy utilizing the Grubbs ruthenium catalyst. With this macrocyclization approach, a key intermediate lactam has been prepared which will be utilized in a total synthesis of the natural product.
