220472-55-9Relevant academic research and scientific papers
The synthesis of conformationally constrained analogues of the ACE inhibitor Idrapril
Jones, Iwan G.,Jones, Wyn,North, Michael
, p. 279 - 290 (1999)
A conformationally constrained analogue 3 of the ACE inhibitor Idrapril has been prepared by a five-step synthesis. The key step in the synthesis is the desymmetrization of endo-norborn-5-ene-2,3-dicarboxylic anhydride 4 by reaction with t-butyl (S)-prolinate.
