The synthesis of conformationally constrained analogues of the ACE inhibitor Idrapril

Article abstract of DOI:10.1016/S0040-4020(98)01033-3

A conformationally constrained analogue 3 of the ACE inhibitor Idrapril has been prepared by a five-step synthesis. The key step in the synthesis is the desymmetrization of endo-norborn-5-ene-2,3-dicarboxylic anhydride 4 by reaction with t-butyl (S)-prolinate.