220493-40-3Relevant academic research and scientific papers
Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor
Hadac, Elizabeth M.,Dawson, Eric S.,Darrow, James W.,Sugg, Elizabeth E.,Lybrand, Terry P.,Miller, Laurence J.
, p. 850 - 863 (2007/10/03)
An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and selective molecules that act at the same biological target. In this work, we have identified the active
Structurally similar small molecule photoaffinity CCK-A agonists and antagonists as novel tools for directly probing 7TM receptor-ligand interactions
Darrow, James W.,Hadac, Elizabeth M.,Miller, Laurence J.,Sugg, Elizabeth E.
, p. 3127 - 3132 (2007/10/03)
Incorporation of photolabile benzoyl (2a-d) or trifluoromethyl-3H- diazirine (3a-d) substituents into 1,5-benzodiazepine ligands did not significantly impair the rat CCK-A binding affinity of either agonists or antagonists. The modified agonist ligands al
