220496-01-5

Basic information

• Product Name: N-(2-Aminophenyl)-N-(3-methylphenyl)amine
• Synonyms: N-(2-Aminophenyl)-N-(3-methylphenyl)amine;UKRORGSYN-BB BBV-218147
• CAS NO: 220496-01-5
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 198.26
• Mol File: 220496-01-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 341.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• PKA: 5.11±0.10(Predicted)
• CAS DataBase Reference: N-(2-Aminophenyl)-N-(3-methylphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminophenyl)-N-(3-methylphenyl)amine(220496-01-5)
• EPA Substance Registry System: N-(2-Aminophenyl)-N-(3-methylphenyl)amine(220496-01-5)

Safety Data

• Hazardous Substances Data: 220496-01-5(Hazardous Substances Data)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 108-44-1 1-amino-3-methylbenzene 
• 28093-66-5 N-(3-methylphenyl)-2-nitroaniline 

Relevant articles and documents

A green and practical reduction of N-(4-chlorophenyl)-2-nitroaniline and its derivatives to corresponding N-substituted-benzene-1,2-diamines using thiourea dioxide

A new effective approach for synthesizing diverse N-substituted-benzene-1,2-diamines is reported. The treatment of N-substituted-2-nitroanilines with thiourea dioxide in the presence of sodium hydroxide efficiently formed the corresponding N-substituted-benzene-1,2-diamines, including N-(4-chlorophenyl)benzene-1,2-diamine with a good yield of 94%. The by-product is environmentally-friendly urea and is easy to separate from the product by filtration procedure that enhances the convenience of the approach.

ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.