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Pregna-1,4-diene-3,20-dione, 21-[(ethoxycarbonyl)oxy]-11,17-dihydroxy-, (11b)-, also known as Prednisolone 21-Ethylcarbonate, is a derivative of the synthetic corticosteroid Prednisolone (P703740). It is metabolically interconvertible with prednisone and possesses significant anti-inflammatory and immunosuppressive properties.

2205-88-1

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2205-88-1 Usage

Uses

Used in Pharmaceutical Industry:
Pregna-1,4-diene-3,20-dione, 21-[(ethoxycarbonyl)oxy]-11,17-dihydroxy-, (11b)is used as a pharmaceutical agent for its potent anti-inflammatory and immunosuppressive effects. It is particularly effective in treating various conditions such as rheumatoid arthritis, systemic lupus erythematosus, severe allergies, and certain skin diseases.
Used in Medical Treatments:
In the medical field, Pregna-1,4-diene-3,20-dione, 21-[(ethoxycarbonyl)oxy]-11,17-dihydroxy-, (11b)is utilized for its ability to suppress the immune system, making it a valuable component in the treatment of autoimmune diseases and conditions requiring immunosuppression, such as organ transplants.
Used in Corticosteroid Replacement Therapy:
Pregna-1,4-diene-3,20-dione, 21-[(ethoxycarbonyl)oxy]-11,17-dihydroxy-, (11b)is also used in corticosteroid replacement therapy for patients with adrenal insufficiency, where the body does not produce enough natural corticosteroids. It helps to alleviate symptoms and maintain normal bodily functions.
Used in Veterinary Medicine:
In veterinary medicine, Pregna-1,4-diene-3,20-dione, 21-[(ethoxycarbonyl)oxy]-11,17-dihydroxy-, (11b)is employed for its anti-inflammatory and immunosuppressive properties to treat various conditions in animals, similar to its use in human medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 2205-88-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,0 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2205-88:
(6*2)+(5*2)+(4*0)+(3*5)+(2*8)+(1*8)=61
61 % 10 = 1
So 2205-88-1 is a valid CAS Registry Number.

2205-88-1Downstream Products

2205-88-1Relevant academic research and scientific papers

Synthesis of prednicarbate, an unhalogenated topical antiinflammatory derivative of prednisolone-17-ethylcarbonate-21-propionate

Stache,Fritsch,Rupp,Hitzel,Fehlhaber

, p. 1753 - 1757 (2007/10/02)

The synthesis of prednisolone-17-ethylcarbonate-21-propio-nate (prednicarbate, Hoe 777) passing the intermediate products prednisolone 17,12-diethylorthocarbonate and prednisolone-17-ethylcarbonate as well as some physico-chemical properties and spectroscopic data of especially the 1H-NMR- and MS-spectrum, are reported. Prednicarbate has an optimal split of topical/systemic antiinflammatory activity.

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