22050-96-0

Upstream product

• 591-50-4 iodobenzene 
• 579-10-2 N-acetyl-N-methylaniline 
• 117-34-0 2,2-diphenylacetic acid 
• 100-61-8 N-methylaniline 
• 4467-90-7 N-hydroxy-2,2-diphenylacetimidoyl chloride 
• 81838-53-1 N'-Hydroxy-N-methyl-2,2,N-triphenyl-acetamidine 
• 1871-76-7 diphenylacetic acid chloride 

Downstream Products

• 22136-54-5 N-methyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one 

Relevant academic research and scientific papers

Transition metal and base-free synthesis of 3,3-diaryl-2-oxindoles from 2,2,N-triarylacetamides

A transition metal and base-free synthesis of 3,3-diaryl-2-oxindoles has been developed from 2,2,N-triarylacetamides in the presence of montmorillonite K-10 in 1,2-dichlorobenzene under O2 balloon atmosphere.

Photostimulated Reactions of N,N-Disubstituted Amide Enolate Anions with Haloarenes by the SRN1 Mechanism in Liquid Ammonia

The photostimulated reactions of chloro-, bromo-, and iodobenzenes, 1-chloronaphthalene, and 9-bromophenanthrene with the enolate anion of N-methyl-N-phenylacetamide in liquid ammonia gave good yields of substituted products.In the dark, iodobenzene gave 34percent of substitution product, but chlorobenzene did not react.The enolate anion of N,N-dimethylacetamide was only partially soluble in liquid ammonia, but good yields of substitution products were obtained.The enolate anion of N-acetylpiperidine was insoluble in liquid ammonia, but the enolate anion of N-acetylmorpholine was soluble and good yields of substitution products were obtained under photostimulation.It is suggested that these reactions occur by the SRN1 mechanism of aromatic substitution.