220502-40-9Relevant academic research and scientific papers
Synthesis and in vitro Antimicrobial Activity of Nalidixic Acid Hydrazones
Popio?ek, ?ukasz,Biernasiuk, Anna,Malm, Anna
, p. 1589 - 1594 (2016)
A series of nalidixic acid-based hydrazones have been synthesized and evaluated for their in vitro antimicrobial activity using the broth microdilution method against a panel of reference strains of microorganisms, including Gram-positive bacteria, Gram-negative bacteria, and fungi belonging to yeasts Candida spp. and molds Aspergillus spp., Penicillium spp., and Rhizopus spp. Nalidixic acid derivatives were obtained by condensation reaction of nalidixic acid hydrazide with substituted (hetero)aromatic aldehydes. All compounds have been characterized by1H NMR and13C NMR spectra. The antimicrobial activity indicated that compound with indole substituent could be a promising lead for future development of active antifungal agents.
New nalidixic acid–1,3-thiazolidin-4-one hybrids: Design, synthesis and in vitro antimicrobial activity
Popio?ek, ?ukasz,Biernasiuk, Anna
, p. 23 - 27 (2016/12/24)
In this paper, 14 new nalidixic acid–1,3-thiazolidin-4-one hybrid compounds (17–30)were synthesized by the cyclization reaction of corresponding N-substituted nalidixic acid hydrazones (3–16) with mercaptoacetic acid in the presence of 1,4-dioxane. The structures of the obtained compounds were confirmed by means of1H NMR and13C NMR spectroscopy. All newly synthesized hybrids were screened in vitro for antimicrobial activity. The antimicrobial activity assay indicated that compounds 17–30 showed good to moderate antimicrobial activity, especially against Gram-positive bacteria. Moreover, compound 29 inhibited growth of reference strains of Gram-negative bacteria belonging to Enterobacteriaceae family.
Synthesis, spectroscopic characterizations, and biological evalution of some substituted 1-Ethyl-1,4-Dihydro-7-Methyl-4-Oxo-1,8-Naphthyridine-3-Carbohydrazide and their copper complexes
Deeba, Farah,Khan, Misbahul Ain,Abbas, Naeem,Khan, Rauf Ahmad,Ahsan, Muhammad Muneeb
, p. 419 - 428 (2017/06/27)
Summary: Different analogs of 1-ethyl-1, 4-dihydro-7-methyH-4-oxo-1, 8-naphthyridine-3-carbohydrazide (carbonyl hydrazone derivatives of Nalidixic acid, H 1-10) and their copper complexes have been synthesized from reaction of Nalidixic acid hydrazide wit
Synthesis of nalidixic acid based hydrazones as novel pesticides
Aggarwal, Nisha,Kumar, Rajesh,Srivastva, Chitra,Dureja, Prem,Khurana
, p. 3056 - 3061 (2011/08/03)
Thirty-one substituted hydrazones of nalidixic acid hydrazide were synthesized and characterized by spectral techniques. These compounds were evaluated for various biological activities, namely, fungicidal, insecticidal, and nitrification inhibitory activities. The antifungal activity was evaluated against five pathogenic fungi, namely, Rhizoctonia bataticola, Sclerotium rolfsii, Rhizoctonia solani, Fusarium oxysporum, and Alternaria porii. They showed maximum inihibition against A. porii with ED50 = 34.2 151.3 μg/mL. The activity was comparable to that of a commercial fungicide, hexaconazole (ED50 = 25.4 μg/mL). They were also screened for insecticidal activity against third-instar larvae of Spodoptera litura and adults of Callosobruchus maculatus and Tribollium castaneum. Most of them showed 70-100% mortality against S. litura through feeding method at 0.1% dose. These compounds were not found to be effective nitrification inhibitors.
