220545-48-2Relevant academic research and scientific papers
Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists
Huryn, Donna M.,Ashwell, Susan,Baudy, Reinhardt,Dressen, Darren B.,Gallaway, William,Grant, Francine S.,Konradi, Andrei,Ley, Robert W.,Petusky, Susan,Pleiss, Michael A.,Sarantakis, Dimitri,Semko, Christopher M.,Sherman, Mary M.,Tio, Cesar,Zhang, Lu
, p. 1651 - 1654 (2004)
A pro-drug strategy to identify orally efficacious VLA-4 antagonists is described. Potential pro-drugs were evaluated for their physical chemical characteristics and in vitro properties, including solubility, stability, permeability and plasma stability.
STEROID SPARING AGENTS AND METHODS OF USING SAME
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Page/Page column 441-442, (2010/02/14)
This invention relates generally to the use of a steroid sparing agent for the preparation of a medicament for the treatment of inflammatory bowel diseases (IBD), asthma, multiple sclerosis (MS), rheumatoid arthritis (RA), graft versus host disease (GVHD), host versus graft disease, and various spondyloarthropathies, comprising administering a steroid sparing immunoglobulin or small molecule composition to a patient in need thereof. The invention also relates generally to combination therapies for the treatment of these conditions.
