22056-04-8

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 107-13-1 acrylonitrile 
• 109-72-8 n-butyllithium 
• 1156004-08-8 2-(butylselanylmethyl)-3-(4-chlorophenyl)-3-hydroxypropanenitrile 

Downstream Products

• 131469-64-2 2-(4-Chloro-benzoyl)-oxirane-2-carbonitrile 
• 172658-58-1 (E)-3-(4-Chloro-phenyl)-2-hydroxymethyl-acrylonitrile 
• 139413-83-5 (E)-2-(bromomethyl)-3-(4-chlorophenyl)acrylonitrile 
• 139413-84-6 (Z)-2-Bromomethyl-3-(4-chloro-phenyl)-acrylonitrile 
• 852287-74-2 3-(4-chloro-phenyl)-2-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-propionitrile 
• 1010396-76-5 C₁₇H₁₂NO₂Cl 

Relevant academic research and scientific papers

Iodine-catalyzed thioallylation of indoles using Bunte salts prepared from Baylis-Hillman bromides

Metal-free iodine-catalyzed regioselective thioallylation of indoles has been accomplished at room temperature using Bunte salts prepared from Baylis-Hillman bromides. The resulting multi-functional C3 thioallylated indoles exhibit ample structural divers

Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a biaryl axis, prepared by the Suzuki coupling reaction, Morita–Baylis–Hillman adducts, heteroatomlinked diarylpyridines prepared by Buchwald–Hartwig crosscoupling reactions and imidazo[1,2a]pyridines prepared by the Groebke–Blackburn–Bienaymé multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the biaryl compounds and Morita–Baylis–Hillman products but not the Groebke–Blackburn–Bienaymé products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.

A one-pot three-step multicomponent synthesis of functionalized allyl dithiocarbamates using Baylis–Hillman reaction

A one-pot, pseudo five-component, highly diastereoselective, and mild procedure for the synthesis of functionalized allyl dithiocarbamates is developed. The Baylis–Hillman (BH) reaction of aromatic (heteroaromatic) aldehydes and activated alkenes using DA

ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

Efficient synthesis of N-allylated 2-nitroiminoimidazolidine analogues from Baylis–Hillman bromides

Various Baylis–Hillman–derived new N-allylated 2-nitroiminoimidazolidine analogs were efficiently prepared using potassium carbonate as base. Simple workup procedure, excellent yields, and mild reaction conditions are the salient features of this method. All the synthesized compounds are screened for their larvicidal activity on fourth instar mosquito larvae, Culex quinquefasciatus.

Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents

A series of pyran derivatives (5–27) were synthesized in good yields by utilizing Baylis–Hillman chemistry and were further investigated for their in vitro anticancer, antibacterial, and antifungal activities. Most of the tested compounds exhibited promis

Morita-Baylis-Hillman reaction in eutectic solvent under aqueous medium

A series of deep eutectic solvents (DESs) based on choline chloride were prepared and used in the Morita-Baylis-Hillman (M-B-H) reaction. Research showed that the composite solvent (1ChCl/2Gly DES-H2O) is a very effective solvent media for all

Versatile O- and S-functionalized 1,2,3-triazoliums: Ionic liquids for the Baylis-Hillman reaction and ligand precursors for stable MIC-transition metal complexes

The efficient synthesis of O- and S-functionalized 1,2,3-triazoliums is reported. Owing to their physical properties, these cations are efficient ionic liquids for Baylis-Hillman addition under mild reaction conditions. Simultaneously, the functionalizati

Cl-H2O: An efficient and versatile solvent system for the DABCO-catalyzed Morita-Baylis-Hillman reaction

An efficient and versatile solvent-catalyst system, [HyEtPy]Cl-H2O-DABCO, has been developed and used in the Morita-Baylis-Hillman reaction. Under the mild reaction conditions, Morita-Baylis-Hillman proceeds very quickly and efficiently. This protocol has notable advantages such as eco-friendliness, ease of work-up and reuse of ionic liquid conveniently, which could help reduce disposal costs and contribute to the development of a new solvent-catalyst system for use in green and continuous chemical processes.

Synthesis of new triazolium-based ionic liquids and their use in the Morita-Baylis-Hillman reaction

A series of 1,3,4-trialkyl-1,2,3-triazolium ionic liquids were synthesized via click chemistry and used as reaction media for the Morita-Baylis-Hillman (MBH) reaction.