220569-80-2Relevant academic research and scientific papers
Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells
Brooke, Darby G.,Shelley, Elizabeth J.,Roberts, Caroline G.,Denny, William A.,Sutherland, Robert L.,Butt, Alison J.
, p. 7033 - 7043 (2011)
A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
