220586-52-7

Upstream product

• 220586-50-5 diethyl (S_s,1S,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 3167-63-3 diethyl chloromethylphosphonate 
• 10419-77-9 diethyl iodomethanephosphonate 

Downstream Products

• 220586-49-2 diethyl(-)-S-(3-phenyl-2-H-azirin-2-yl) phosphonate 
• 68839-08-7 (S)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 220586-54-9 diethyl(-)-(2S,3R)-(3-phenyl-2-H-aziridin-2-yl) phosphonate 

Relevant academic research and scientific papers

Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of α-amino phosphonates

An aza-Darzens reaction, involving the addition of chloromethylphosphonate anions to enantiopure sulfinimines, has been developed for the asymmetric synthesis of aziridine 2-phosphonates. Best results involve cyclization of the syn and anti diastereomeric

Asymmetric synthesis of aziridine 2-phosphonates and azirinyl phosphonates from enantiopure sulfinimines

Enantiopure sulfinimine (S)-4 was employed in a Darzens-type synthesis of aziridine 2-phosphonates (-)-7/(+)-8 which were transformed into α-amino phosphonates (S)-11/(R)-12 and the first enantiopure examples of azirinyl phosphonates 13-15.