22059-22-9

Basic information

• Product Name: N-Hydroxyacetamidine
• Synonyms: n-hydroxy-ethanimidamid;n-hydroxyethanimidamide;(1E)-N'-HYDROXYETHANIMIDAMIDE;ACETAMIDE OXIME;METHYLAMIDOXIME;N-HYDROXYACETAMIDINE;Acetamide oxime, 95+%;ethylidyne amidoxime
• CAS NO: 22059-22-9
• Molecular Formula: C₂H₆N₂O
• Molecular Weight: 74.08
• Product Categories: pharmacetical
• Mol File: 22059-22-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 134 °C
• Boiling Point: 197.9 °C at 760 mmHg
• Flash Point: 73.5 °C
• Appearance: White/Powder, Crystals and/or Chunks
• Density: 1.19 g/cm³
• Vapor Pressure: 0.0936mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 7.48±0.69(Predicted)
• CAS DataBase Reference: N-Hydroxyacetamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Hydroxyacetamidine(22059-22-9)
• EPA Substance Registry System: N-Hydroxyacetamidine(22059-22-9)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39
• RTECS: AC6900000
• HazardClass: IRRITANT
• Hazardous Substances Data: 22059-22-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

InChI:InChI=1/C2H6N2O/c1-2(3)4-5/h5H,1H3,(H2,3,4)

Upstream product

• 75-05-8 acetonitrile 

Downstream Products

• 638220-06-1 6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-quinoline 
• 755029-81-3 N-({3-[3-(3-methoxy-4-nitrophenyI)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]propanoyl}oxy)ethanimidamide 
• 291305-37-8 cis-(1S)-N-methyl-7-(5-(3-methyl-1,2,4-oxadiazolyl))-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 871343-71-4 C₁₅H₁₄Cl₂N₄OS 
• 335259-25-1 8-(4-Fluoro-phenyl)-4-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 143771-70-4 5-(4'-(2-Butyl-4-chloro-5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-imidazolylmethyl)biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 
• 937079-53-3 3-{2-[3-(4-fluorophenyl)-isoxazol-5-yl]-2-[(E)-propoxyimino]-ethoxy}-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-benzoic acid methyl ester 
• 1164139-98-3 1,1-dimethylethyl 4-(4-((Z)-1-aminoethylideneaminooxycarbonyl)-2-fluorophenyl)piperazine-1-carboxylate 
• 1192208-77-7 3,5-dichloro-N-[5-(3-methyl-[1,2,4]oxadiazol-5-yl)naphthalen-2-yl]phenylsulphonamide 
• 705279-08-9 N-[(1Z)-N-hydroxyethanimidoyl]-5-methoxy-2-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]benzamide 
• 865706-92-9 3-methyl-5-phenylsulfanylmethyl-[1,2,4]oxadiazole 
• 936246-88-7 N-(3-(benzyloxy)-5-bromopyridin-2-yl)-4-(2-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl)thiazol-2-amine 
• 947143-84-2 1-Benzyl-4-benzylamino-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (1-hydroxyimino-ethyl)-amide 
• 1263941-52-1 3-methyl-5-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis of various 3-substituted 1,2,4-oxadiazole-containing chiral β3- and α-amino acids from Fmoc-protected aspartic acid

Various 3-substituted chiral 1,2,4-oxadiazole-containing Fmoc-β 3- and α-amino acids were synthesized from FmoC-(L or D)-Asp(OtBu)-OH and Fmoc-L-Asp-OtBu, respectively, in three steps (i.e., condensation of an aspartyl derivative with different