220615-80-5

Upstream product

• 77-71-4 5,5-dimethyl-imidazolidine-2,4-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1555932-55-2 1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione 
• 1179804-62-6 1-(2-benzylbenzyl)-5,5-dimethylimidazolidine-2,4-dione 
• 1179804-12-6 1-(2-benzylbenzyl)-3-(4-methanesulfonylphenyl)-5,5-dimethylimidazolidine-2,4-dione 
• 1179804-61-5 1-(2-benzylbenzyl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

IMIDAZOLIDIN-2-ONE COMPOUNDS AS PRMT5 MODULATORS

The present invention relates to the derivatives of compound of formula (I) and pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and use thereof as PRMT5 inhibitors. Th

CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF

The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein R1, R2, Qa, Y1, Z, A, B, Qx, E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxal ine-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound.

NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.