220623-24-5

Upstream product

• 186429-20-9 (S,E)-methyl 4-((tert-butoxycarbonyl)amino)-5-((tert-butyldiphenylsilyl)oxy)pent-2-enoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 892865-81-5 C₈H₁₃NO₃ 
• 220623-04-1 (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester 
• 220623-03-0 (1S,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 
• 220623-23-4 (1R,2S,5S,6R)-3-aza-3-benzyl-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-methanol 

Downstream Products

• 220623-25-6 (1R,2S,5S,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-carboxylic acid 

Relevant academic research and scientific papers

Cyclopropanation reactions of pyroglutamic acid-derived synthons with akylidene transfer reagents

The cyclopropanation of unsaturated lactams 1 and 3 derived from pyroglutamic acid with nucleophilic alkylidene transfer reagents is investigated. Good-to-modest yields of cyclopropanes were obtained with most sulfur ylides explored. Syn/anti selectivity was found to be dependent on the synthon as well as the sulfur ylide. This cyclopropanation methodology is used in the synthesis of arginine and glutamic acid analogues.

Efficient synthesis of cyclopropane-fused heterocycles with bromoethylsulfonium salt

Lord of the rings! [3.1.0] bicyclic ring systems were synthesized using bromoethylsulfonium triflate and easily available amino acid/aza-Morita-Baylis- Hillman-derived allylic amines. The simple transformation displays a very high degree of diastereoselec