220645-25-0Relevant articles and documents
Amide groups switch selectivity: C-H trifluoromethylation of α,β-unsaturated amides and subsequent asymmetric transformation
Li, Lei,Guo, Jing-Yao,Liu, Xing-Guo,Chen, Su,Wang, Yong,Tan, Bin,Liu, Xin-Yuan
, p. 6032 - 6035 (2014)
The first direct C-H β-trifluoromethylation of unsubstituted or α-alkyl-substituted α,β-unsaturated carbonyl compounds under metal-free conditions was realized with excellent regio- and stereoselectivity as well as a very broad substrate scope. Both olefi