220647-56-3 Usage
Description
rac S 33138, also known as Rac-S 33138, is a novel benzopyrano[3,4-c]pyrrole derivative that acts as a potent and selective dopamine D3 receptor antagonist. It is the racemate of S 33138 (S080700) and has potential applications as an antipsychotic agent. rac S 33138 does not interact with histamine H1 and muscarinic receptors, making it a promising candidate for specific therapeutic interventions.
Uses
Used in Pharmaceutical Industry:
rac S 33138 is used as a preferential dopamine D3 versus D2 receptor antagonist for its potential antipsychotic properties. The compound's selectivity for dopamine D3 receptors over D2 receptors and its lack of interaction with histamine H1 and muscarinic receptors make it a valuable tool in the development of new treatments for psychiatric disorders.
Used in Research and Development:
In the field of neuroscience and pharmacology, rac S 33138 is used as a research tool to study the role of dopamine D3 receptors in various brain functions and disorders. Its selective antagonism of dopamine D3 receptors helps researchers understand the underlying mechanisms of dopamine-related conditions and develop targeted therapies.
Used in Drug Discovery:
rac S 33138 serves as a lead compound in the search for new antipsychotic medications. Its unique properties, such as selective dopamine D3 receptor antagonism and lack of interaction with histamine H1 and muscarinic receptors, make it an attractive starting point for the design and synthesis of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 220647-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,4 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 220647-56:
(8*2)+(7*2)+(6*0)+(5*6)+(4*4)+(3*7)+(2*5)+(1*6)=113
113 % 10 = 3
So 220647-56-3 is a valid CAS Registry Number.
220647-56-3Relevant articles and documents
Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonists
Dubuffet, Thierry,Newman-Tancredi, Adrian,Cussac, Didier,Audinot, Valerie,Loutz, Annie,Millan, Mark J.,Lavielle, Gilbert
, p. 2059 - 2064 (1999)
A new series of benzopyrano[3,4-c]pyrrole derivatives were synthesized and evaluated for their interaction with dopamine D3 versus D2 receptors. Amongst these compounds, 4x (S 33084) was found to be a potent and selective dopamine D3 receptor antagonist.
