220652-31-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 247200-40-4 (4S,5S,2Z)-5-Methyl-4-[(4-methoxy-2,3,6-trimethylphenylsulfonyl)amino]hept-2-en-1-ol 
• 288254-04-6 N-((1S,2S)-1-Formyl-2-methyl-butyl)-4-methoxy-2,3,6-trimethyl-benzenesulfonamide 
• 247200-35-7 Ethyl (4S,5S,2Z)-5-methyl-4-[(4-methoxy-2,3,6-trimethylphenylsulfonyl)amino]hept-2-enoate 

Relevant academic research and scientific papers

Selective synthesis of cis-2-vinyl-3-alkylaziridines and 3-pyrrolines from common intermediates (Z)-4-N-arylsulfonylaminoalk-2-en-1-ols

A simple method for the synthesis of both cis-2-vinylaziridines and 3-pyrrolines from common intermediate (Z)-4-(N-arylsulfonyl)amino-4-alkylbut-2-en-1-ols, is described. Palladium(0)-catalyzed reactions of methyl carbonates of the N-protected (Z)-4-amino-4-alkylbut-2-en-1-ols yield predominantly cis-3-alkyl-2-vinylaziridines. Alternatively, upon exposure to sodium hydride, methanesulfonates derived from N-protected (Z)-4-amino-4-alkylbut-2-en-1-ols give exclusively the corresponding 3-pyrrolines in high yields. A synthesis of biologically important (S)-3,4-dehydroproline is also presented.