220658-95-7Relevant academic research and scientific papers
Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model
Keenan, Richard M.,Lago, M. Amparo,Miller, William H.,Ali, Fadia E.,Cousins, Russell D.,Hall, Leon B.,Hwang, Shing-Mei,Jakas, Dalia R.,Kwon, Chet,Louden, Calvert,Nguyen, Thomas T.,Ohlstein, Eliot H.,Rieman, David J.,Ross, Steven T.,Samanen, James M.,Smith, Brian R.,Stadel, Jeffrey,Takata, Dennis T.,Vickery, Lynne,Yuan, Catherine C. K.,Yue, Tian-Li
, p. 3171 - 3176 (2007/10/03)
In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (αvβ3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and iv pharmacokinetics for demonstration of efficacy in a rat restenosis model.
