220682-45-1Relevant academic research and scientific papers
Design and synthesis of a series of (2R)-N4-hydroxy-2-(3-hydroxybenzyl)-N1- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors
Yao,Wasserman,Chao,Reddy,Shi,Liu,Covington,Arner,Pratta,Tortorella,Magolda,Newton,Qian,Ribadeneira,Christ,Wexler,Decicco
, p. 3347 - 3350 (2007/10/03)
A pharmacophore model of the P1′ site, specific for aggrecanase, was defined using the specificity studies of the matrix metalloproteinases and the similar biological activity of aggrecanase and MMP-8. Incorporation of the side chain of a tyrosine residue
