403657-46-5Relevant academic research and scientific papers
Potent P1′ biphenylmethyl substituted aggrecanase inhibitors
Yao, Wenqing,Chao, Michael,Wasserman, Zelda R.,Liu, Rui-Qin,Covington, Maryanne B.,Newton, Robert,Christ, David,Wexler, Ruth R.,Decicco, Carl P.
, p. 101 - 104 (2002)
A series of cis-1(S)2(R)-amino-2-indanol based compounds with a biphenylmethyl group at the P1′ position was found to be potent aggrecanase inhibitors. Both compounds 2j and 2n possessed very high aggrecanase affinity (IC50=1.5 nM), and showed
