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(3-benzoyl-2-methoxyphenyl)acetic acid, also known as rofecoxib, is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits potent analgesic, anti-inflammatory, and antipyretic properties. It functions by inhibiting the production of prostaglandins, which are important mediators of pain and inflammation.
Used in Pharmaceutical Industry:
(3-benzoyl-2-methoxyphenyl)acetic acid is used as an analgesic, anti-inflammatory, and antipyretic agent for the treatment of conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. However, its use is now limited due to safety concerns over its cardiovascular risks, leading to its withdrawal from the market in 2004.

22071-32-5

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22071-32-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 22071-32-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,0,7 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22071-32:
(7*2)+(6*2)+(5*0)+(4*7)+(3*1)+(2*3)+(1*2)=65
65 % 10 = 5
So 22071-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O4/c1-20-16-12(10-14(17)18)8-5-9-13(16)15(19)11-6-3-2-4-7-11/h2-9H,10H2,1H3,(H,17,18)

22071-32-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-benzoyl-2-methoxyphenyl)acetic acid

1.2 Other means of identification

Product number -
Other names EINECS 244-762-4

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22071-32-5 SDS

22071-32-5Downstream Products

22071-32-5Relevant academic research and scientific papers

2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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Page 28, (2010/02/08)

Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

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