22077-44-7

Upstream product

• 36383-22-9 Bis disulfide 
• 2253-60-3 O,O-diphenyl phosphorodithioic acid 
• 3426-89-9 phenyl phosphorodichloridite 
• 5382-00-3 Diphenyl phosphorochloridite 
• 18961-96-1 O-phenylphosphorodichloridothioate 
• 139-02-6 sodium phenoxide 
• 108-95-2 phenol 
• 14156-07-1 diphenylthiophosphoric acid 

Downstream Products

• 112520-71-5 p-tolyl-amidothiophosphoric acid O,O'-diphenyl ester 
• 112520-70-4 (4-methoxy-phenyl)-amidothiophosphoric acid O,O'-diphenyl ester 
• 31860-18-1 diethyl-amidothiophosphoric acid O,O'-diphenyl ester 
• 131534-81-1 2-diphenoxythiophosphoryliminothiazolidine 
• 131534-84-4 {2-[(E)-Diphenoxy-thiophosphorylimino]-thiazolidin-3-yl}-phosphonothioic acid O,O-diphenyl ester 
• 147056-42-6 C₁₄H₁₅N₂O₃PS 
• 129769-26-2 N-allyl-N'-(diphenoxyphosphinothioyl)-S-ethylisothiourea 
• 131534-87-7 C₂₂H₂₂N₂O₃P₂S₃ 
• 131746-34-4 5-methyl-3-methylimino-2-diphenoxythiophosphorylisoxazoline 
• 140655-54-5 C₁₆H₁₉N₂O₃PS 
• 129769-35-3 5-bromo-1-(diphenoxyphosphinothioyl)-2-(ethylthio)-1,4,5,6-tetrahydropyrimidine 
• 118150-12-2 N-(2,3-dibromopropyl)-N'-(diphenoxyphosphinothioyl)-S-ethylisothiourea 
• 1228072-89-6 C₂HF₃O₂*C₁₇H₂₁N₂O₂PS 
• 1257875-00-5 C₂₃H₃₁N₂O₄PS 

Relevant academic research and scientific papers

Hydrogen Bond Donor Catalyzed Cationic Polymerization of Vinyl Ethers

The synthesis of high-molecular-weight poly(vinyl ethers) under mild conditions is a significant challenge, since cationic polymerization reactions are highly sensitive to chain-transfer and termination events. We identified a novel and highly effective h

Thiophosphate and thiophosphonate analogues of glucose-1-phosphate: Synthesis and enzymatic activity with a thymidylyltransferase

Synthetic methods were investigated for the preparation of O and S-glucosyl thiophosphates and glucosyl 1C-thiophosphonate. Four protected glucosyl thiophosphate compounds were synthesized and characterized as precursors to glucose 1-thiophosphate. The ef

Synthesis and cholinesterase inhibitory activity of n-phosphorylated / n-tiophosphorylated tacrine

Background: Alzheimer’s disease (AD) is progressive and irreversible neurodegenera-tive disorder. Current pharmacotherapy is not able to stop progression of the disease and can only improve cognitive functions. Therefore, new drugs are being sought that w

Curcumin phosphate compound, preparation method and uses thereof

The present invention relates to a curcumin phosphate compound, a preparation method and uses thereof, and belongs to the field of pharmaceutical chemistry, wherein the structural general formula of the compound is defined in the specification, X is O or

A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates

In this study, we describe a new and easy synthetic approach to variously substituted triazoles based on the reaction of imidates with phosphorylated hydrazine in good yields. A general mechanism of the reactions was also proposed. Characterization of the products was carried out by several analytical and spectroscopic tools including infrared and nuclear magnetic resonance spectroscopies (1H,13C NMR,31P NMR).

Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study

We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.

Thiophosphoramide-based cooperative catalysts for Bronsted acid promoted ionic diels-alder reactions

Three's a crowd: The combination of a Bronsted acid and a hydrogen-bond donor cocatalyst was found to promote various ionic [2+4] cycloadditions under mild reaction conditions (see scheme; Ts=4-toluenesulfonyl) . Thiophosphoramides are the most effective cocatalysts because of the stronger counterion activation effect resulting from three, rather than two, hydrogen bonds involved in anion binding.

A new strategy for the synthesis of pyridine amides, phosphorylated quinoline amides and their thio-analogues

A new strategy for the synthesis of pyridine amides, phosphorylated quinoline amides and their thio-analogues has been developed. The direct reaction between in situ generated mixed phosphoric-carboxylic anhydrides with primary amines allowed a simultaneo

Kinetics and mechanism of the aminolysis of aryl phenyl chlorothiophosphates with anilines

(Chemical Equation Presented) Kinetic studies of the reactions of aryl phenyl chlorothiophosphates (1) and aryl 4-chlorophenyl chlorothiophosphates (2) with substituted anilines in acetonitrile at 55.0°C are reported. The negative values of the cross-interaction constant ρXY (ρXY = -0.22 and -0.50 for 1 and 2, respectively) between substituents in the nucleophile (X) and substrate (Y) indicate that the reactions proceed by concerted SN2 mechanism. The primary kinetic isotope effects (kH/kD = 1.11-1.13 and 1.10-1.46 for 1 and 2, respectively) involving deuterated aniline nucleophiles are obtained. Front- and back-side nucleophilic attack on the substrates is proposed mainly on the basis of the primary kinetic isotope effects. A hydrogen-bonded, four-center-type transition state is suggested for a front-side attack, while the trigonal bipyramidal pentacoordinate transition state is suggested for a back-side attack. The MO theoretical calculations of the model reactions of dimethyl chlorothiophosphate (1′) and dimethyl chlorophosphate (3′) with ammonia are carried out. Considering the specific solvation effect, the front-side nucleophilic attack can occur competitively with the back-side attack in the reaction of 1′.