220774-94-7

Upstream product

• 676-58-4 methylmagnesium chloride 
• 220774-92-5 Acetic acid (2S,3R,4R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-5-oxo-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl ester 
• 917-64-6 methyl magnesium iodide 
• 16758-34-2 1-thiophenyl-β-D-galactopyranoside 
• 220774-90-3 Acetic acid (2S,3R,4S,5S,6R)-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl ester 
• 220774-88-9 (2S,3R,4S,5S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3,5-diol 
• 220774-86-7 phenyl 1-thio-6-O-triphenylmethyl-β-D-galactopyranoside 
• 76-83-5 trityl chloride 

Downstream Products

• 220775-00-8 4-Oxo-pentanoic acid (2R,3R,4R,5R,6S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-3-methyl-6-phenylsulfanyl-2-trityloxymethyl-tetrahydro-pyran-4-yl ester 
• 220774-98-1 (2R,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-6-phenylsulfanyl-2-trityloxymethyl-tetrahydro-pyran-3,4-diol 

Relevant academic research and scientific papers

Diastereofacial selection in the 1,2-addition of MeMgX and MeLi to 4- oxo sugar: Efficient synthesis of 4-C-methyl-1-S-β-D-gluco- and galactopyranoside building blocks of moenomycin

The stereochemical course of the 1,2-addition upon treatment of various 1-thio-4-oxo sugars with MeMgX and MeLi has been determined. The effects of reagent, solvent, and neighboring functionalities in the gluco/galacto (non- chelation/chelation controlled

Expeditious route to F unit building block of moenomycin A

Synthesis of the versatilely sugar unit building block of moenomycin A, Phenyl 2-O-levulinoyl-4-C-methyl-1-thio-β-D-glucopyranosiduronic acid is described starting from phenyl 1-thio-β-D-galactopyranoside. The key synthetic steps included: (I) Regioselect