220820-74-6Relevant articles and documents
A novel, thioacetal based linker for solid-phase synthesis
Huwe, Christoph M.,Kuenzer, Hermann
, p. 683 - 686 (1999)
Commercially available (±)-α-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mitsunobu reactions, respectively. The products were easily cleaved from solid support by treatment with [bis(trifluoroacetoxy)iodo]benzene.