220841-11-2

Upstream product

• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 106-96-7 propargyl bromide 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 

Downstream Products

• 62176-24-3 5-chloro-2-(2-propyn-1-yloxy)benzoic acid 

Relevant academic research and scientific papers

Silver(I) and gold(I)-promoted synthesis of alkylidene lactones and 2H-chromenes from salicylic and anthranilic acid derivatives

Ag(I) and Au(I) efficiently catalyze the cycloisomerization of terminal alkynoic acids into methylene seven-membered ring lactones. Depending on the metal, divergent reaction pathways were found for non terminal alkynoic acids. While Ag(I) led to lactones, Au(I) led to 2H-chromenes coming from the hydroarylation of the alkyne.

A facile synthesis of methyl 5-amino-6-chloro-2h-1-benzopyran-8-carboxylate derivatives

Methyl 6-chloro-5-pivaloylamino-2H-1-benzopyran-8-carboxylate (4d) was prepared in good yield as a result of the thermal cylcization of methyl 5-chloro-4-pivaloylamino-2-propargyloxybenzoate (3d) using N,N-diethylaniline as a solvent.