220847-35-8Relevant academic research and scientific papers
Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.
Chen,Trilles, Richard,Miklowski, Dorota,Huang, Tai-Nan,Fry, David,Campbell, Robert,Rowan, Karen,Schwinge, Virginia,Tilley, Jefferson W
, p. 1679 - 1682 (2007/10/03)
A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists char
